Product Description

HumaSkin SCREEN is a native human-derived dermal screening multi-well plate providing 6 test conditions. HumaSkin SCREEN is coated with Huma DermiMatrix (skin ECM), Huma AdipoMatrix (adipose ECM), HumaElastin (human skin elastin), HumaDerm (human skin collagen type I), and HumaMatrix (universal human ECM) to help determine which matrix protein is best suited for your cell research needs. Each well is designed to deliver precise and independent testing conditions, ensuring the reliability of your data.

Huma DermiMatrix retains the native matrix proteins and growth factors found in human skin including collagens (Type I, III, IV), elastin, glycoproteins (laminin, fibronectin, tenascin, fibrillin), and glycosaminoglycans (hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparan sulfate, and heparin). Huma DermiMatrix supports various cell types, including keratinocytes, fibroblasts, melanocytes, adipocytes, endothelial cells, and more.

Huma AdipoMatrix retains the native matrix proteins and growth factors found in human adipose tissue including collagens (Type I, III, IV, VI), elastin, glycoproteins (fibronectin, laminin, tenascin) and glycosaminoglycans (hyaluronic acid, chondroitin sulfate and dermatan sulfate). Huma AdipoMatrix supports various cell types, including adipocytes, macrophages, fibroblasts, stem cells, and more.

Elastin is a crucial structural protein found in various connective tissues throughout the body, providing elasticity and resilience to organs and tissues that require the ability to stretch and recoil [1]. It is primarily present in tissues such as the skin, blood vessels, lungs, and ligaments. Elastin is composed of amino acids – predominantly glycine, valine, alanine, and proline, with unique cross-linking patterns that contribute to its distinctive properties [2].

Type I Collagen is the most abundant type of collagen in the human body, as a major structural matrix protein in skin, and many other tissues (bone, tendon, and fibrous connective tissues). Type I collagen is a heterotrimer composed of one α2(I) chain and two α1(I) chains [3]. It is characterized by the presence of three regions on SDS-PAGE corresponding to molecular weights. HumaDerm, human skin collagen type I, presents all three regions and chains with very minimal fragmented proteins in between.

HumaMatrix, native human-derived ECM, is considered the universal human ECM which retains the native matrix proteins and growth factors found in human tissue including collagen, elastin, laminin, glycosaminoglycans and many other matrix proteins.

HumaSkin SCREEN reduces labor time, consumable costs, and accelerates therapy delivery without affecting the quality of cells.

Tissue Source

The matrix proteins used in HumaSkin SCREEN are isolated from human tissue sourced strictly from American Association of Tissue Banks (AATB) accredited and FDA registered tissue banks and organ procurement organizations (OPOs). Humabiologics strives to meet research needs by providing high quality biomaterials obtained from tissue partners who comply with requirements for transplantable human tissues under 21 CFR 1271 of the FDA.

Precautions and Disclaimer

The matrix proteins used in HumaSkin SCREEN are obtained from human tissue that has been tested and found negative for a minimum of HIV-1, HIV-2, hepatitis B, and hepatitis C, as well as other infectious agents. Please review the Safety Data Sheet (SDS) for information regarding hazards and safe handling practices. HumaSkin SCREEN is for research use only and is not intended for human use, diagnosis, screening, household, food, or other uses.

Storage Conditions/Expiration

HumaSkin SCREEN should be stored at 2-8 °C upon receipt. Do not freeze coated plates. Research grade products have a shelf life of 3 months from receipt.